Roy C. Ziegelstein, MD, Department of Medicine, Division of Cardiology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Depressed mood is common after a myocardial infarction and is associated with increased mortality risk. Although mild forms of depression often resolve without specific treatment, moderate to severe depression is typically longer lasting. Depression is particularly unlikely to resolve spontaneously in those who are socially isolated, a common problem in older individuals. Patients may be screened for depression using one of several short and valid instruments. If antidepressant treatment is indicated, a selective serotonin reuptake inhibitor is preferred and should be combined with efforts to improve social support, to address medication adherence issues and to encourage participation in a cardiac rehabilitation program.
Key words: depression, myocardial infarction, screening, social support, antidepressants.

Kunin-Lunenfeld Applied Research Unit 2nd Annual Conference at Baycrest Centre for Geriatric Care, October 18, 2002

Joanna Goldberg, MSc, Associate Editor, Geriatrics & Aging.

Speakers

1. The Role of Anti-inflammatories and the Inflammatory Hypothesis in the Prevention of Alzheimer Disease
   Presented by Patrick McGeer, MD, Vancouver, BC.
2. Decreasing Dementia Risk and Minimizing Cognitive Decline with Participation in Engaging Activities and Memory Rehabilitation
   Presented by Angela Troyer, PhD, CPsych, Baycrest Centre for Geriatric Care, Toronto, ON.
3. Pharmacological Strategies for Prevention of Alzheimer Disease
   Presented by Serge Gauthier, MD, FRCPC, McGill Centre for Studies in Aging, Montreal, QC.

The goal of research at the Baycrest Centre for Geriatric Care is to provide a scientifically based understanding of diseases and disorders of the elderly. Through various educational methods, staff are trained to implement new practices in assessment, management and rehabilitation. The ultimate goal is to find preventative measures to delay or eliminate the onset of disease. Three of the eight lectures at this conference that touched on how future research, clinicians and care providers may help to achieve these goals in patients with dementia are presented in this report.

I.

Karen Beattie, BSc, PhD Candidate and Dr. A. Papaioannou, MSc, MD, FRCP(C), Associate Professor of Medicine; Department of Geriatrics, McMaster University, Hamilton, ON.
Dr. P. Boulos, MD, FRCP(C) and Dr. J.D. Adachi, MD, FRCP(C), Professors of Medicine; Department of Rheumatology, McMaster University, Hamilton, ON.

Osteoporosis is a major health concern in Canada, affecting 25% of women and 12% of men. Vertebral compression fractures, the most common of all osteoporotic fractures, are clinically diagnosed only 30% of the time. Treatment for such fractures is primarily pharmacological. However, newer, non-invasive methods of treatment, namely vertebroplasty and kyphoplasty, stabilize compression fractures, provide pain relief and even improve posture and functional ability. While vertebroplasty involves the injection of a cement product into one or more compressed vertebrae, kyphoplasty adds another step of inserting a balloon into the vertebra to re-establish original vertebral height. Clinical studies of these procedures suggest kyphoplasty provides better symptomatic relief and is associated with fewer complications than vertebroplasty. However, further randomized, controlled evidence comparing these procedures is required.
Key words: kyphoplasty, vertebroplasty, osteoporosis, vertebral fracture, compression fracture.

Dr. Neil Baum, MD, Urologist and Clinical Associate Professor of Urology, Tulane Medical School, New Orleans, LA, USA.
Dorothea Torti, Stanford University, CA, USA.

Prostate cancer is the most common cancer in men in North America. One of the treatment options is medical castration using LHRH agonists to reduce the production of testosterone by the Leydig cells in the testes. One of the side effects of this class of agents is hot flashes, which can be very disabling and can affect a man's quality of life. This article will discuss the pathophysiology of hot flashes and the treatment of this common side effect with natural and synthetic female hormones, as well as non-hormonal therapies.
Key words: prostate cancer, hot flashes, LHRH agonists, hormone therapy.

David H. Fitchett MD, FRCP(C), St Michael's Hospital, University of Toronto, Toronto, ON.

For the diabetic patient, hypertension more than doubles the risk of myocardial infarction, stroke and cardiovascular death, and is central in the development of diabetic nephropathy. Control of hypertension is an important vascular protective measure. However, the thresholds and goals of antihypertensive treatment have fallen as trials have shown improved outcomes with blood pressures reduced to 120/80mmHg or less. Although reducing blood pressure to the lower target levels must be the primary goal of treatment, the use of diuretics and angiotensin-converting enzyme inhibitors should be considered as first-line therapy in the diabetic patient. Both agents have been demonstrated to improve a wide range of cardiovascular outcomes compared to other antihypertensive medications.
Key words: diabetes, hypertension, nephropathy, blood pressure control.

Xiumei Feng, MD, MSc and Norm R.C. Campbell, MD, Division of General Internal Medicine, University of Calgary, Calgary, AB.

Normal blood pressure is less common than "hypertension" in the elderly, and most hypertension is primary, or essential. Nevertheless, secondary hypertension in the elderly should be considered in patients with suggestive features, as the prevalence of secondary hypertension increases with age. The most common causes of secondary hypertension in the elderly are renal parenchyma diseases, primary aldosteronism, renal vascular stenosis and drug induced. Timely recognition and treatment of secondary hypertension will reduce the morbidity and mortality associated with uncontrolled hypertension.
Key words: hypertension, high blood pressure, elderly, secondary causes.

Sheldon Tobe, MD, FRCP(C), Assistant Professor of Medicine, Nephrology, University of Toronto; Division Director Nephrology, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON.
Sudha Cherukuri, MD, DNB(Nephrology), Clinical Fellow, University of Toronto, Toronto, ON.

Isolated systolic hypertension (ISH) is a common disorder in the elderly. Several studies have shown a constant positive and graded association between the level of systolic blood pressure and subsequent mortality from cardiovascular disease and stroke. ISH is defined as an elevated systolic pressure above 160mmHg and a diastolic pressure below 90mmHg. Arterial stiffening is the main cause of increasing systolic pressure in the elderly. The finding of high systolic blood pressure with diastolic below 90mmHg is a marker of higher cardiovascular risk and an indication to follow this patient more closely. The placebo-controlled SHEP and Syst-Eur trials have demonstrated that the treatment of ISH with diuretics or long-acting calcium channel blockers results in a marked reduction in cardiovascular events and stroke.
Key words: hypertension, isolated systolic hypertension, clinical trials, drug therapy, elderly.

Robert J. Petrella, MD, PhD, President, Canadian Coalition for High Blood Pressure Prevention and Control; Associate Professor and Medical Director, Canadian Centre for Activity and Aging, University of Western Ontario, London, ON.

Hypertension is the leading reason for office visits to primary care physicians and is also the leading chronic disease of aging. Given the aging demographic in Canada, its burden on the health care system will grow, making prevention and treatment of hypertension a priority. Solid evidence regarding effective pharmacological therapies in hypertension is available, yet diagnosis and treatment rates remain poor. Likewise, solid evidence regarding the effect of non-pharmacological or lifestyle interventions also is available for clinicians. Furthermore, lifestyle interventions may potentiate the effects of pharmacological therapies due to their inherent modification of positive chronic disease behaviour, resulting in improved maintenance of treatment interventions. With pressure to see many patients in the busy primary care practice, clinicians should resist the "quick-fix" approach to treating hypertension solely by pharmacological means. Consideration of lifestyle modification is worth the time in terms of obtaining sustained control of a growing population at risk.
Key words: hypertension, lifestyle interventions, behaviour change.

Kelly B. Zarnke, MD, MSc, Departments of Medicine, Epidemiology & Biostatistics, University of Western Ontario, London, ON, and on behalf of the Canadian Hypertension Education Program (CHEP).

Poor blood pressure control, particularly among the older Canadian population, remains an important cause of preventable cardiovascular morbidity and mortality. It behooves Canadian health care workers to identify, treat and control hypertension. Recent trials, including ALLHAT and LIFE, add to the information clinicians need to achieve these targets. ALLHAT establishes the central role of thiazide-like diuretics for many hypertensive patients. ALLHAT demonstrates that good blood pressure control can be achieved in the majority of hypertensive patients if a systematic effort is maintained. LIFE adds important information regarding angiotensin receptor blockers as an effective alternative to the other commonly used classes of antihypertensive drugs, particularly among patients with diabetes or isolated systolic hypertension. Finally, the Canadian Hypertension Education Program will continue to produce and disseminate annually updated systematic reviews and recommendations related to the assessment and management of hypertension.
Key words: hypertension, recent clinical trials, clinical practice guidelines.

Alexander I. Aspinall, MD, PhD and Jon B. Meddings, MD, FRCPC, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, AB.

The inflammatory bowel diseases (IBD)--Crohn's disease (CD) and ulcerative colitis (UC)--have a second peak of onset after the age of 60. Discerning IBD from alternate diagnoses is a great challenge in the geriatric population, as other diseases commonly encountered in the elderly can mimic IBD. The possibilities include ischemic colitis, diverticulitis and infectious colitis. Diagnosing and treating IBD should involve consultation with a gastroenterologist, but the approaches do not vary significantly from the strategies used in younger patients. Therapeutic modalities used in younger age groups are also applicable to the geriatric population, but great attention needs to be given to side effects and drug interactions.
Key words: inflammatory bowel, crohn's disease, ulcerative colitis, differential diagnosis

Epidemiology and Pathophysiology
The inflammatory bowel diseases--Crohn's disease (CD) and ulcerative colitis (UC)--are illnesses of unknown cause.