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Pancreatic Cancer-A Review of Current Management Principles

Pancreatic Cancer-A Review of Current Management Principles

Teaser: 


Christine B. Brezden-Masley, MD, PhD, Staff Physician, Department of Medicine, Division of Hematology and Oncology, St. Michael’s Hospital; Assistant Professor, Department of Medicine, University of Toronto, Toronto, ON.
Monika K. Krzyzanowska, MD, MPH, Staff Physician, Department of Medical Oncology & Hematology, Princess Margaret Hospital; Assistant Professor, Department of Medicine, University of Toronto, Toronto, ON.

Pancreatic cancer is the fourth and fifth leading cause of cancer-related death for men and women, respectively (following lung, colon, and prostate cancers in men; lung, breast, colon, and ovarian cancers in women). Patients usually present with advanced disease, making curative attempts difficult. Surgery is the only curative therapy; however, local disease recurrence with or without spread to distant organs occurs in over 80% of patients. Attempts at better therapeutic modalities are necessary in order to improve outcome in this disease. This review will focus on staging, risk factors, and therapies for resectable, locally advanced, and advanced (metastatic) pancreatic cancer. Novel molecular targeted therapies will also be briefly highlighted.
Key words: pancreatic cancer, chemotherapy, radiation therapy, Whipple procedure, staging.

Diagnosis and Management of Lung Cancer in Older Adults

Diagnosis and Management of Lung Cancer in Older Adults

Teaser: 

Natasha B. Leighl, MD, FRCPC, Assistant Professor of Medicine, Division of Medical Oncology, Princess Margaret Hospital/University Health Network; Department of Medicine, University of Toronto, Toronto, ON.

Lung cancer is the leading cause of cancer-related mortality in North America and most commonly affects older patients. Patterns of investigation and treatment in older individuals differ, which may compromise outcome. Older patients should be carefully evaluated, using comprehensive geriatric assessment, to assess for function, functional reserve, comorbidities, polypharmacy, and other issues. Fit patients with few or no comorbidities should be offered standard treatments such as surgical resection for early-stage lung cancer with adjuvant chemotherapy, combined modality treatment (chemotherapy and radiation) for locally advanced disease, and systemic chemotherapy with supportive care for metastatic disease. Frail patients should be reviewed to optimize function and comorbid illnesses, and then considered for other treatment alternatives aimed at minimizing toxicity while still trying to maximize the curative or palliative potential of lung cancer therapy depending upon disease stage.
Key words: lung cancer, aging, chemotherapy, surgery, radiation, treatment.

Treatment Strategies for Breast Cancer

Treatment Strategies for Breast Cancer

Teaser: 

The accredited CME learning activity based on this article is offered under the auspices of the CE department of the University of Toronto. Participating physicians are entitled to one (1) MAINPRO-M1 credit by completing this program, found online at www.geriatricsandaging.ca/cme

Christine B. Brezden-Masley, MD, PhD, Staff Physician, Department of Medicine, St. Michael’s Hospital; Assistant Professor, Department of Medicine, University of Toronto, Toronto, ON.
Maureen Trudeau, BSc, MA, MD, Acting Regional Vice President, Cancer Services--Clinical; Head, Division of Medical Oncology/Hematology, Sunnybrook & Women’s College Hospital Sunnybrook Campus; Head, Systemic Therapy Program, Toronto Sunnybrook Regional Cancer Centre; Associate Professor, Department of Medicine, University of Toronto, Toronto, ON.

Breast cancer is the most common cause of cancer mortality in women over 65 years of age. Older women with breast cancer are usually understaged and undertreated as a result of factors such as significant patient comorbidities, patient preferences, age-biases, and poor cognition. Furthermore, women over the age of 70 have been excluded from many breast cancer clinical trials, making treatment conclusions difficult. Patients’ characteristics (including age and comorbidities) should be considered when deciding on the final treatment, a decision ideally made by both the treating physician and the patient. This review will discuss current treatment strategies for breast cancer patients, with a focus on the older population.
Key words: breast cancer, older adults, staging, systemic chemotherapy, radiotherapy.

A Review of Neuropathic Pain Treatments for the Older Adult

A Review of Neuropathic Pain Treatments for the Older Adult

Teaser: 


The accredited CME learning activity based on this article is offered under the auspices of the CE department of the University of Toronto. Participating physicians are entitled to one (1) MAINPRO-M1 credit by completing this program, found online at www.geriatricsandaging.ca/cme

Hsiupei Chen, MD, Carolina Pain Consultants and Critical Health Systems, Raleigh, North Carolina, USA.
Randall P. Brewer, MD, The Spine Institute, Willis Knighton Health System, Shreveport, Louisiana, USA.

Neuropathic pain (NP) results from injury or dysfunction in the processing of sensory information in the nervous system. It occurs in a wide array of disease processes and may involve complex management strategies. A comprehensive approach utilizing proven pharmacologic and nonpharmacologic therapies can be used to return function and improve quality of life that has been lost because of pain. In the older population, age-related physiologic and pharmacodynamic alterations, coexisting diseases, and the prevalence of polypharmacy must be considered when selecting therapies for neuropathic pain.
Key words: neuropathic pain, older adults, neuropathy, pain, analgesics.

Complementary and Alternative Therapies for Pain in Older Adults

Complementary and Alternative Therapies for Pain in Older Adults

Teaser: 


Aileen Burford-Mason, PhD, President, Holistic Health Research Foundation of Canada, Toronto, ON.
Trish Dryden RMT, MEd, Coordinator of Massage Therapy Research and Development, School of Applied Arts and Health Sciences, Centennial College, Scarborough, ON.
Merrijoy Kelner, PhD, Professor Emerita, Institute for Life Course and Aging, University of Toronto, Toronto, ON.
Paul Richard Saunders, PhD, ND, DHANP, Professor of Materia Medica, Canadian College of Naturopathic Medicine, North York, ON.
Mark Ware, MD, MRCP(UK), MSc, Assistant Professor, Departments of Anesthesia and Family Medicine, McGill University, Montreal, QC.

Complementary and Alternative Medicine (CAM) is defined as a group of diverse medical and health care practices, products, and systems that are not presently considered part of conventional medicine but are increasingly being used. For older patients already receiving multiple drugs, such practices are attractive as nonpharmacological approaches to pain management. This review highlights several CAM therapies, including acupuncture treatment, massage therapy, and several natural health products supported by recent research.
Key words: pain, acupuncture, massage, Devil’s claw, glucosamine.

One Step at a Time

One Step at a Time

Teaser: 


A. Mark Clarfield, MD, Chief of Geriatrics, Soroka Hospital, Beer-sheva, Israel; Sidonie Hecht Professor of Geriatrics, Ben-Gurion University of the Negev, Beer-sheva, Israel; Staff Geriatrician of the Division of Geriatric Medicine, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, QC.

When I lived in Montreal I was asked to consult on an 89-year-old Chinese man who had suffered his first cerebrovascular accident four weeks earlier. After three days of stabilization in an acute-care medical ward, he had been transferred to a rehabilitation hospital for physiotherapy.

“Mr. Chan” returned to our acute-care institution after three weeks at the rehabilitation facility. A note explained that because the patient had stopped improving, he no longer needed the bed in that hospital facility. What he now required, we had been told, was an acute-care hospital bed where he could await transfer to a long-term bed--something that might, in our situation, take over a year!

When I went up to his ward it took me several minutes to find Mr. Chan because he had gone for a walk with his wife to a solarium 100 yards away in another wing of the hospital. After hunting down my quarry, I asked him to return to his room. As he did so, I observed his gait while he negotiated the crowded corridor with the aid of a walker. His elderly wife was by his side, but I noted that she was not physically supporting him in any way.

Because it was clear to me that he spoke little English, I greeted him in Mandarin, “Nee how.” (I know how to say hello in 27 languages. Although I cannot say much more than that in most of them, saying hello really does help break the ice.) He looked quizzical, and I asked him, “Hong Kong? Beijing?” When he answered, “Hong Kong,” I knew what kind of interpreter to call upon.

Our hospital admitting service soon sent around one of the laboratory technicians who spoke fluent Cantonese, and for the next half-hour she acted as my able translator.

Q. What brought you to the hospital?
A. Mr. Chan: I had a stroke. I was transferred to another hospital, but they sent me back here.

Q. Why?
A. Mr. Chan: Because they said that they could not help me anymore.

Q. What do you want to do?
A. Mr. Chan: I want to go home to be with my wife.

Q. What’s stopping you?
A. Mr. Chan: Our bedroom and washroom are on the second floor of our house, but I can’t get up there. After my second week in the convalescent hospital I was sent home for a weekend, but when I had to urinate I could not get up the stairs to the bathroom.

Q. What happened?
A. Mr. Chan: I wet my pants, and I was very ashamed in front of my wife. This had never happened to me before.

I was beginning to get the picture. I excused myself and called the physician in charge of the case at the rehabilitation hospital. He explained that Mr. Chan had been sent back to us because he had “plateaued,” and that “the family does not want him home; they want him placed in a nursing home.”

I asked whether the doctor had access to an interpreter to talk with this essentially unilingual Chinese couple. He explained that he had not, but that he had spoken with a daughter on the phone, who had expressed her parents’ wishes.

Returning to the older couple, I repeated the other physician’s version of the story. They looked at me with disbelief in their eyes. “No, not at all,” exclaimed the woman. “If only I can get my husband up the stairs twice a day, we can take care of him at home. I don’t want him placed. Not at all!”

My mind was made up. I called in our physiotherapist, occupational therapist, and social worker. Together with our nurses, we got the man up and walking each day. With the aid of the interpreter, we also taught him how to negotiate stairs under his wife’s watchful supervision. Six weeks later, he returned home.

What lessons can be drawn from this case? First, one must not rush older rehabilitation candidates. Stroke rehabilitation is a slow process at any age, but the older victim requires more time than a younger person with the same level of disability. To pronounce that the patient had “plateaued” after three weeks was simply not appropriate. Tincture of time, applied p.r.n., was required here.

Second, although not viewing the world through rose-coloured glasses, the physician must be optimistic and must transmit this optimism to the patient. If you are not enthusiastic about the chances of recovery, why should a patient contradict you? Older people, especially immigrants, still maintain an inflated sense of the doctor’s omniscience. Why not use this psychological “laying on of hands” to the patient’s benefit, especially when the prognosis is not clearly poor?

Third, one must recognize when the forecast is not dismal. In this case, Mr. Chan had suffered no previous cognitive deficit, was otherwise in reasonably good health, and had a supportive wife who was certain she did not want to place him in a long-term care facility. It helped that he was an eager student once the “teachers” entered the classroom. The fact that I could not find him in his room that first day because he and his wife had gone on their own Long March made me wonder why the patient had been sent back to us from the rehabilitation hospital.

Fourth, one should use the other members of the health care team. As a physician, I thought that the patient might be able learn to climb stairs. The physiotherapist not only confirmed this impression, but she actively and expertly taught him his steps. The occupational therapist made a home visit to ensure that any aids that could help Mr. Chan would be in place by the time he returned home.

Finally, one must talk with the patient. Without an intelligent and capable interpreter, nothing could have been done with this particular patient and family. This fact may seem obvious, but it is amazing how often the all-important history is taken in a perfunctory manner. In Mr. Chan’s case, carefully communicating with the patient meant the eventual difference between an independent life at home and an inappropriate long-term institutionalization. Apart from the benefit to the patient and his family, consider the health care dollars saved by such a relatively short but intensive period of rehabilitation.

The main difference between young and old is the older person’s loss of reserve--physiological, psychological, and sociological. However, just because your patient is older does not mean that he or she cannot benefit from attempts at rehabilitation. On the other hand, the physician experienced in the care of older adults will not want to squander precious recources on a poor rehabilitation candidate. Knowing the difference, having faith in your judgment, and pushing the patient and family as far and as fast as they want to go will reap benefits not only for the medical system but for the patient and the family, as well as for your sense of satisfaction with a difficult job well done. When it comes to rehabilitating older adults, we would do well to remember the old Chinese saying: “A journey of 10,000 li must begin with a single step.”

Polymyalgia Rheumatica

Polymyalgia Rheumatica

Teaser: 


Noleen Smith, 4th-year Medical Studentt, Guy's King's and St Thomas' Medical School, London, UK.
Mark Harding, MD, MBBCH(Wits), FRACGP, Dip Occ Health, BSc (QS) Hons, General Practitioner, Inverell, New South Wales, Australia.

Polymyalgia rheumatica (PMR) has a female predominance and typically occurs in people over 50 years of age. PMR usually presents as pain and stiffness in the neck, shoulder, and pelvic areas. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels are used to determine disease activity. PMR is thought to be a systemic component of giant cell arteritis with aborted vasculitis. Other studies have looked at infectious agents as a causative factor. PMR is treated using a corticosteroid regime that, in turn, causes many unwanted side effects. Various methods to decrease these unwanted effects have been studied, including the addition of methotrexate as a steroid-sparing agent and intramuscular injection of methylprednisolone rather than oral prednisolone.
Key words: erythrocyte sedimentation rate, C-reactive protein, vasculitis, corticosteroids, side effects.

Asthma in Older Adults

Asthma in Older Adults

Teaser: 

Sidney S. Braman, MD, FACP, FCCP, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Brown Medical School & Rhode Island Hospital, Providence, RI, USA.

Asthma is an inflammatory disease of the airways manifested by diffuse airflow obstruction, complete or partial reversibility of the airflow obstruction, and bronchial hyper-responsiveness. Asthma may occur at any age and is more prevalent in older compared to younger adults. Unfortunately, the diagnosis of asthma is frequently overlooked as patients underreport their symptoms, physicians underutilize pulmonary function testing, and symptoms are mistaken for other diseases such as COPD and heart failure. The medications used to treat the older asthmatic are effective, well tolerated, and the same as those used to treat younger patients.
Key words: asthma, reversible airflow obstruction, airway remodelling, beta-agonist therapy, inhaled corticosteroids.

Sudden Deafness, Part 1: Diagnosis and Treatment

Sudden Deafness, Part 1: Diagnosis and Treatment

Teaser: 

Maurice H. Miller, PhD, Department of Speech-Language Pathology & Audiology/Steinhardt School of Education, New York University, New York, NY, USA.
Jerome D. Schein, PhD, Professor Emeritus, New York University, New York, NY, USA; Adjunct Professor, University of Alberta, Edmonton, AB.

Hearing loss that occurs instantaneously or over a period of a few days without immediately apparent cause is called Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL). In part 1 of this series, the diagnosis and initial treatment of this condition are described in relation to most patients’ demands for active and aggressive intervention. Part 2 (to follow in the next issue) will address rehabilitation.
Key words: audiology, deafness, diagnosis, hearing aids, idiopathic, otology, rehabilitation, unilateral and bilateral hearing loss, sensorineural.

Medication Review for the 10-Minute Consultation: The NO TEARS Tool

Medication Review for the 10-Minute Consultation: The NO TEARS Tool

Teaser: 


Tessa L. Lewis, MD, General Practitioner, Carreg Wen Surgery, Church Road, Blaenavon, Torfaen, UK.

The NO TEARS structure can aid efficient medication review within a 10-minute consultation. It is a flexible system that can be tailored to the individual practitioner’s consultation style:
Need/indication
Open questions
Tests
Evidence
Adverse effects
Risk reduction
Simplification/switches

Key words: medication review, NO TEARS, primary care, older adults, polypharmacy.