Richard Holland, BA, BM BCh, DA, DPH, MFPH, PhD, Senior Lecturer in Public Health Medicine, School of Medicine Health Policy & Practice, University of East Anglia, Norwich, UK.
David Wright, BPharm, PhD, Senior Lecturer in Pharmacy Practice, School of Chemistry and Pharmacy, University of East Anglia, Norwich, UK.

Older people consume a disproportionate quantity of drugs compared to younger people. Furthermore, the volume and cost of these drugs is increasing markedly. In theory, drugs are prescribed to reduce both morbidity and mortality but can also cause harm, particularly amongst older people. Medication review has been advocated as a technique to reduce such problems, whilst at the same time ensuring patients gain maximum benefit from their drugs. Whilst medication review seems a logical solution to inappropriate prescribing in general and adverse reactions in particular, evidence that specific interventions are effective at reducing morbidity or mortality is lacking.
Key words: medication review, adverse drug reactions, medication appropriateness, pharmacists, background.

Marian Garfinkel, EdD, Medical Researcher and Adjunct Professor, Temple University, College of Health Professions, Department of Kinesiology; Medical Researcher, University of Pennsylvania, School of Medicine, Department of Rheumatology; Veterans Administration Hospital, Department of Rheumatology; Director, BKS Iyengar Yoga Studio of Philadelphia, Philadelphia, PA, USA.

By broadening yoga’s application beyond stress-related ailments to include preventative and curative therapies, physicians today have an advantage in treating patients’ illnesses and disorders. Specifically, yoga therapy complements patients’ traditional medical treatment of osteoarthritis and other bone and joint disorders. Following anatomical guidelines, yoga teachers can adapt postures (asanas) to ensure patients’ organs, joints, and bones are aligned to achieve physiologic changes. Recent studies performed by this author assessing the effect of yoga therapy on rheumatic diseases, such as osteoarthritis, and repetitive strain injuries, such as carpal tunnel syndrome, showed that yoga therapy caused physiologic changes, relieved pain, and improved motion.
Key words: osteoarthritis, yoga, Iyengar, exercise, repetitive strain injuries.

Barbara Resnick, PhD, CRNP, FAAN, FAANP, Professor, University of Maryland School of Nursing, Baltimore, MD, USA.
Marcia G. Ory, PhD, MPH, Professor, Social and Behavioral Health; Director, Active for Life National Program Office, School of Rural Public Health, The Texas A & M University System, College Station, TX, USA.
Michael E. Rogers, PhD, CSCS, FACSM, Associate Professor, Department of Kinesiology and Sport Studies, Center for Physical Activity and Aging, Wichita State University, Wichita, Kansas, USA.
Phillip Page, MS, PT, ATC, CSCS, Manager, Clinical Education & Research, The Hygenic Corporation, Akron, OH, USA.
Roseann M. Lyle, PhD, Purdue University, Department of Health and Kinesiology, West Lafayette, IN, USA.
Cody Sipe, MS, Program Director, A.H. Ismail Center, Purdue University, West Lafayette, IN, USA.
Wojtek Chodzko-Zajko, PhD, Professor, Department Head of Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Terry L. Bazzarre, PhD, Senior Program Officer, Robert Wood Johnson Foundation, Princeton, NJ, USA.

Physical activity helps to maintain function, health, and overall quality of life for older adults. It is challenging, however, for health care providers and others who work with older adults to know what type of activity to encourage older adults to engage in, and how to motivate them to initiate and adhere to physical activity and exercise over time. The purpose of this piece is to provide an overview of physical activity for older adults and provide the resources needed to evaluate older adults and help them establish safe and appropriate physical activity programs, as well as providing motivational interventions that will eliminate the barriers to exercise and optimize the benefits.
Key words: exercise, screening, motivation, self-efficacy, outcome expectations.

The accredited CME learning activity based on this article is offered under the auspices of the CE department of the University of Toronto. Participating physicians are entitled to one (1) MAINPRO-M1 credit by completing this program, found online at www.geriatricsandaging.ca/cme

Shabbir M.H. Alibhai, MD, MSc, FRCPC, Department of Medicine, University Health Network; Department of Medicine and Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON.

More than one-half of new cancers and over 70% of cancer deaths in industrialized nations occur in adults age 65 or older. Systematic screening has been associated with reductions in cancer-related mortality for a variety of cancers, including breast, cervical, and colorectal cancer. While increasing numbers of older adults are living beyond 70, few guidelines address cancer screening in this group of older adults. In this article, evidence-based guidelines are reviewed for cancer screening in adults and limitations of screening studies with respect to older adults are discussed. A framework for deciding when to stop cancer screening in older adults is presented based on estimating remaining life expectancy, which incorporates age, comorbidity, and functional status.
Key words: cancer screening, aged, mass screening, overdiagnosis, cancer mortality.

Geriatrics & Aging 2005;9,October 2005,51-54.

Dear Editor,

I very much enjoyed Dr. Jerrilynn Prior’s article entitled “Symptomatic Menopause--What Are the Safe and Effective Options?” in the October 2005 edition of your journal. I have three questions.

Question 1-Does Dr. Prior recommend the addition of a progestin for women with an intact uterus using vaginal estrogens for dryness/dysparunia?

Question 2-In figure 1, she suggests that women with disturbing hot flushes combined with osteoporosis take transdermal estradiol along with daily micronized progesterone at a dose of 300 mg. In the text of her article, she states that this dose of OMP is equivalent to 10 mg of MPA. This seems like a higher dose of MPA than most would use for daily dosing. Is this correct?

Question 3-Is there evidence to assure us that unopposed progestin therapy (as she suggests as treatment for severe vasomotor symptoms without osteoporosis) is safe?

Again, thanks very much for the informative article.

Sincerely,

A. Lewis
Family Medicine
Calgary, AB

Deborah Radcliffe-Branch, PhD, University of Montreal, Centre de Recherche, Institut universitaire de gériatrie de Montréal, Montréal, QC.
Cara Tannenbaum, MDCM, MSc, Assistant Professor, Department of Medicine, Division of Geriatrics, University of Montreal, Centre de Recherche, Institut universitaire de gériatrie de Montréal, Montréal, QC.

Older women are one of the most rapidly growing segments of the Canadian population. This growth necessitates an evaluation of the quality and breadth of care women receive to promote successful aging in later life. Older women’s perceptions of health priorities being addressed by the current health care system and those for which improvements are required are reviewed. Recommendations include screening for memory loss, falls, muscle weakness, depression, and urinary incontinence. Guidelines for assessment and prevention as well as the adoption of a patient-centred approach to care are suggested to address the broader context of promoting physical, emotional, and social well-being for older women.
Key words: older women’s health, health priorities, patient-centred care, screening guidelines, primary care.

Wendy Duggleby, DSN, RN, AOCN, Associate Professor, College of Nursing, University of Saskatchewan, Saskatoon, SK.
David Popkin, BSc, MD, CM, FRCSC, FSOGC, FACOG, Executive Director, Saskatoon Cancer Center; Head, Division of Oncology, College of Medicine, University of Saskatchewan; Head, Department of Oncology, Saskatoon Health Region, Saskatoon, SK.

What is it that patients at the end of life want to know? What is the best way to provide the information? A review of the scientific literature was conducted to answer these two questions. The findings suggested that, regardless of age or culture, patients at the end of life wanted information about their illness and prognosis. The expertise of the physician, his/her relationship with the patient, and the use of hopeful communication styles were important factors in how patients understood the information provided. Honest and factual communication fostered hope and quality of life at the end of life.
Key words: physician-patient communication, end of life, literature review, palliative care.

Peter Pommerville, BA, MD, FRCS(C), Director of Research, Can-Med Clinical Research, Inc.; Clinical Instructor, University of British Columbia; Clinical Instructor, University of Victoria; Consulting Urologist, Vancouver Island Health Authority, Vancouver, BC.

It is estimated that 50% of men between 40 and 70 have erectile dysfunction (ED). The number of men with ED rises to 65% or greater over age 70. Despite the fact that men in this age range have significant medical comorbidities causing their ED, they have often cared for a spouse with a terminal illness. In search of companionship, they become acquainted with a woman who has just been through a similar circumstance. Therefore, it’s usual for men to have performance anxiety contributing to their ED. Proper diagnosis and assessment to determine the etiology of ED is usually done by the primary care physician, with possible follow-up by an urologist or psychiatrist if the main cause is deemed to be organic or psychological, respectively. In some cases, there is overlap as medications such as antidepressants may interfere with sexual function.
Primary care physicians, geriatricians, and allied health care professionals charged with the management of these older men should be empathetic towards their sexual health. Safe and effective treatments for ED are available to permit these couples to enjoy a healthy sexual experience in their elder years.
Key words: erectile dysfunction, diabetes, vardenafil, sildenafil, tadalafil.

Karin H. Humphries, MBA, DSC, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC.
Janet McElhaney, MD, Department of Geriatrics, University of British Columbia, Vancouver, BC.

The growth in information about hormone replacement therapy (HRT) over the past few years has been impressive. This review summarizes the latest information on HRT and cardiovascular disease, osteoporotic fractures, and cognitive function. The risks of HRT (e.g., stroke, breast cancer, and venous thromboembolism) clearly outweigh the benefits (e.g., reduction in osteoporotic fractures). The use of HRT for primary or secondary prevention of coronary heart disease or to decrease the risk of cognitive dysfunction is also not supported. While the evidence in older adults is substantial, there is some controversy regarding the effectiveness of HRT initiated in women at the start of menopause.
Key words: hormone replacement therapy, cardiovascular disease, osteoporosis, cognitive function, dementia.

Emerging drug therapies for dementia are increasingly chosen to tackle molecular targets important in Alzheimer’s disease (AD) pathobiology. Amyloid oligomers, amyloid deposits, and neurofibrillary tangles (NFTs) are characteristic findings in AD. Hence, drugs that interfere with these proteinaceous aggregates are receiving the most attention: a) alpha, beta, and gamma secretase modulators, b) inhibitors of amyloid beta (Ab) aggregation, and c) anti-Ab immunologic strategies. Oxidative stress and inflammatory reactions appear part of a loop of neurotoxicity with the proteinacous aggregates. Antioxidants and anti-inflammatory compounds have thus received much attention. Finally, other compounds may work by a variety of other mechanisms.
Key words: Alzheimer’s disease, amyloid, secretase inhibitors, antioxidants, anti-inflammatory agents.