Guido Falcone, MD, Department of Neurology, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Ji Y. Chong, MD, Assistant Professor of Neurology, Columbia University, New York, NY, U.S.A.

Stroke is a common disease in the older population. Many gender differences are seen in the epidemiology, outcomes, and treatment of geriatric stroke. Although these differences are not fully understood, recognition of gender differences may help with appropriate treatment and improve outcomes.
Key words: stroke, gender, outcomes, prevention, treatment.

Elizabeth A. Johnson, RN, PhD(c), Board Certified Geriatric Clinical Nurse Specialist, Doctoral Candidate, Indiana University School of Nursing; Department of Adult Health, Indiana University School of Nursing, Indianapolis, IN, USA.
Tamilyn Bakas, RN, DNS, FAHA, Associate Professor, Department of Adult Health, Indiana University School of Nursing, Indianapolis, IN, USA.
Linda S. Williams, MD, Chief of Neurology, Roudebush Veterans Administration Medical Center; Research Coordinator, VA Stroke QUERI; Associate Professor of Neurology, Indiana University School of Medicine; Research Scientist, Regenstrief Institute, Indianapolis, IN, USA.

Depression, the most frequent neuropsychological problem after stroke, is greatly influenced by the complex relationships between the neurobiological and psychological changes that occur after stroke. Post-stroke depression leads to negative rehabilitation outcomes including less participation in therapy, extended recovery time, significantly decreased quality of life, and increased utilization of health care resources. Because of the high prevalence of post-stroke depression, all stroke survivors should be screened early in the rehabilitation process. Use of a biopsychosocial framework acknowledges the multifactorial etiology of post-stroke depression and contributes to effective, evidence-based treatment. Attention to the needs of the family caregivers further promotes successful post-stroke rehabilitation.
Key words: stroke, depression, risk factors, recovery, treatment.

Nikolai Steffenhagen MD, Calgary Stroke Program, University of Calgary, Calgary, AB.
Michael D. Hill, MD, MSc, FRCPC, Calgary Stroke Program, University of Calgary, Calgary, AB.

The majority of strokes occur among the older adult population. Typically, ischemic stroke can be classified by mechanism, and this is the most practical way to think about stroke since it has a direct bearing on the approach to prevention. It is not enough to simply consider that a past stroke implies a need for antiplatelet therapy or anticoagulant therapy without consideration of cause. In this article, we discuss the use of preventive strategies within the context of antithrombotics and according to stroke mechanism.
Key Words: stroke prevention, geriatric, octogenerian, vascular risk factors, carotid stenosis, atrial fibrillation.

Weerasak Muangpaisan, MD, FRCPT, Assistant Professor, Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand; visiting fellow, Harris Manchester College, University of Oxford, Oxford, U.K.

Cases of dementia are increasing due to longer life expectancy of the world population. Physicians should be able to recognize common dementia syndromes. After excluding reversible causes of dementia, there are four common dementia syndromes, which are Alzheimer’s disease, vascular dementia, dementia with Lewy body, and frontotemporal dementia. The key points of clinical differences of these dementia syndromes are summarized in this article.
Key words: Alzheimer’s disease, vascular dementia, dementia with Lewy body, frontotemporal dementia, Parkinson’s disease.

Mary Anne Huggins, MD, CCFP, DABHPC, Palliative Care Services, Toronto General Hospital, University Health Network; Assistant Professor, Department of Family and Community Medicine, University of Toronto, Toronto, ON.
Laura Brooks, BScN, MScN, ACNP, Palliative Care Services, Toronto General Hospital, University Health Network, Toronto, ON.

Discussing end-of-life care with older patients is very important, as it ensures their preferences are known and they retain control over their care decisions even when they may no longer be actively involved in them. Unfortunately, these discussions do not always occur, and when they do occur, they are not always done well. There are patient and physician barriers to advanced care planning. Physicians may lack the skills necessary to accomplish the task of making decisions for future care. In this article we discuss advanced care planning, its importance as well as related challenges and barriers. We then outline a practical approach to advanced care planning for older adults.
Key words: end-of-life care, advance directives, advanced care planning, living wills, substitute decision-maker.

Alberto Matteelli, MD, Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.
Anna Cristina Carvalho, MD, Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.
Veronica Dal Punta, MD, Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.

The number of international travellers is steadily increasing, paralleled by the number of persons with travel-related diseases. Fever in the returning traveller should always raise suspicion of severe and potentially life-threatening infections. Therefore, physicians should be familiar with the most common syndromes, relevant diagnostic procedures, optimal treatment regimens, and referral criteria. This review gives a general overview of the pathogens causing fever in the returning traveller, their clinical presentation, and standard management procedures.
Key words: fever, travel, older adults, tropical diseases, vaccination.

Irene Turpie, MB, ChB, MSc, FRCP(C), FRCP (Glas), Professor Emeritus, McMaster University, Hamilton, Ontario.
Leigh Hunsinger, BA, Medical Student, McMaster University, Hamilton, Ontario.

Africa, with its many countries and ethnic groups, has a population of 800 million people and the highest rate of growth of the older adult population in the world. Urbanization and the HIV/AIDS epidemic are changing the traditional role of older adults. The epidemiological transition from acute infections to chronic diseases is occurring more slowly in Africa than in other continents but it is occurring. Many older persons are malnourished and live in poverty. Hypertension, stroke, osteoarthritis, chronic respiratory and mood disorders are expected to increase in incidence and are increasingly being identified in a continent without the resources or infrastructure as yet to mount preventive campaigns and to treat chronic health conditions. What is known about many older Africans is that they have the capacity to age well through daily exercise and healthy diets low in processed sugar and saturated fats. Aging Africans are generally regarded with respect and dignity. There is much that needs to be done to prevent deleterious aging outcomes for older adults in that continent and there is much we can learn about healthy aging and lifestyle prevention.
Key words: aging, Africa, epidemiological transition, developing nations, HIV/AIDS.

Angela K. Troyer, PhD, CPsych, Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, ON.
Kelly J. Murphy, PhD, CPsych, Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, ON.

Functional decline in dementia causes increased dependence on others and negatively impacts quality of life. Emerging evidence indicates that functional debility can be delayed or minimized by promoting an active lifestyle and using memory strategies. Older adults with active lifestyles maintain higher cognitive abilities and have reduced risks of developing dementia. Furthermore, individuals with dementia show improved cognitive and functional abilities following participation in physically and mentally stimulating activities. Memory strategy application can improve situation-specific memory performance in individuals with mild cognitive impairment and dementia, and has been shown to positively impact perceptions of well-being and functional ability in these individuals.
Key words: active lifestyle, dementia, memory intervention, mild cognitive impairment, rehabilitation.

Indranil Dasgupta, MD, MPh, MBA, Clinical Assistant Professor of Medicine, Division of Cardiology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
Marc A. Tecce, MD, Clinical Assistant Professor of Medicine, Division of Cardiology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
Bernard L. Segal, MD, Professor of Medicine and Director, Division of Cardiology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.

Disorders of the mitral valve such as mitral valve prolapse (MVP), mitral regurgitation, and, to a lesser degree, mitral stenosis are relatively common forms of heart disease. According to the Women’s Heart Foundation, MVP is the most common condition of the heart valves, and while it is more frequently diagnosed in young women, data from the Framingham study suggest that, overall, MVP affects equal numbers of men and women. These conditions often progress over years, frequently causing symptoms among affected older adults. Understanding the etiology, diagnosis, management, and treatment of mitral valve disease is vital for this population. Medical advances and other factors have allowed the general population to live longer, making mitral valve disease significantly more prevalent. An understanding of the details of the physical exam, ECG changes seen in these disorders, x-ray findings, and echocardiographic and catheterization data are critical to providing the necessary standard of care for older adults.
Key words: mitral regurgitation, mitral stenosis, mitral valve prolapse, older adults, heart failure.

Rita Moretti, MD, Clinica Neurologica, Dipartimento Medicina Clinica e Neurologia, Università degli Studi, Trieste, Italy.
Paola Torre, MD, Clinica Neurologica, Dipartimento Medicina Clinica e Neurologia, Università degli Studi, Trieste, Italy.
Rodolfo M. Antonello, MD, Clinica Neurologica, Dipartimento Medicina Clinica e Neurologia, Università degli Studi, Trieste, Italy.

Cerebrovascular disease is a potential cause of vascular dementia. Vascular dementia is not an univocal entity; it encompasses at least four types of dementia: multi-infarct, subcortical, strategic infarct, and posthemorrhage dementia. Vascular dementia does not contain cognitive problems only. There are also noncognitive behavioural alterations. The major noncognitive behavioural situations are depression, anxiety, agitation, delusions, and insomnia. Disorders such as depression, anxiety, and psychosis not only affect the quality of life of a patient but also that of the caregiver. Behavioural disturbances may also contribute to morbidity and are a major cause of institutionalization since they result in inadequate nutrition and sleep and enhance cognitive disruption. Diagnosing depression in the context of vascular dementia is challenging given the overlap of signs and symptoms between depression and dementia. Both disorders can be characterized by apathy and loss of interest, an impaired ability to think, psychomotor agitation, and psychomotor retardation.
Key words: behaviour, subcortical vascular dementia,, vascular dementia, small-vessel dementia.