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cancer

Damaged DNA and Cellular Apoptosis: The Story on Bladder Cancer in the Elderly

Damaged DNA and Cellular Apoptosis: The Story on Bladder Cancer in the Elderly

D'Arcy Little, MD, CCFP
Director of Medical Education,
York Community Services,
Toronto, ON

Munir A. Jamal, MD, FRCSC
Staff Urologist,
Credit Valley Hospital,
Mississauga, ON

Introduction

Cancer, Old Age, and the Meaning of Life

Cancer, Old Age, and the Meaning of Life

Shabbir M.H. Alibhai, MD, MSc, FRCPC
Senior Editor,
Geriatrics & Aging

Recently I saw a 72-year-old woman with metastatic uterine cancer in consultation. She was receiving palliative chemotherapy and our team felt she would benefit from short-term inpatient rehabilitation. Within a week of this consult, I saw an 81-year-old woman with an acute myocardial infarction. My team elected to start her on lipid-lowering therapy.

Response to Therapy in Acute Myeloblastic Leukemia Dependent on Genetic Make-up of Leukemic Cells

Response to Therapy in Acute Myeloblastic Leukemia Dependent on Genetic Make-up of Leukemic Cells

M.D. Minden, M.D., Ph.D., FRCPC
Princess Margaret Hospital
University Health Network
Toronto, ON

Introduction
Leukemias are malignancies of the blood and bone marrow and are classified as either acute or chronic malignancies of the myeloid--red blood cell, granulocyte, platelet lineage--or lymphoid--T or B lymphocyte. In this article we will focus on acute myeloblastic leukemias (AML) and recent advances in their classification and therapy.

Radiation Therapy for the Treatment of Esophageal and Gastric Cancers in the Elderly

Radiation Therapy for the Treatment of Esophageal and Gastric Cancers in the Elderly

Jolie Ringash, MD, MSc
Department of Radiation Oncology,
Princess Margaret Hospital
University Health Network,
Toronto, ON

Multiple Myeloma: The Debilitating Disease that ‘Punches Out’ the Elderly

Multiple Myeloma: The Debilitating Disease that ‘Punches Out’ the Elderly

Dr. Christine I. Chen, MD, FRCPC
Princess Margaret Hospital,
University Health Network,
Toronto, ON

Cancer, Cellular Senescence and Longevity--The Telomere Connection

Cancer, Cellular Senescence and Longevity--The Telomere Connection

Anna Liachenko, BSc, MSc
Managing Editor,
Geriatrics & Aging

The relationship between aging and cancer has its basis in cell cycle alterations. While multiple factors affect cell cycle progression, recent research has directed a great deal of attention to telomere length as a key factor affecting mammalian cell proliferation. This article discusses recent findings with respect to the role of telomeres and telomerase in cancer, cellular aging, and longevity.

Mutant Mice Develop More Serious Forms of Cancer

Mutant Mice Develop More Serious Forms of Cancer

A group of researchers from Harvard have found evidence that telomere attrition in aging telomerase-deficient mice, heterozygous for the p53 tumour suppressor gene, promotes the development of epithelial cancers.