D'Arcy Little, MD, CCFP
Director of Medical Education,
York Community Services,
Toronto, ON
Munir A. Jamal, MD, FRCSC
Staff Urologist,
Credit Valley Hospital,
Mississauga, ON
Introduction
Shabbir M.H. Alibhai, MD, MSc, FRCPC
Senior Editor,
Geriatrics & Aging
Recently I saw a 72-year-old woman with metastatic uterine cancer in consultation. She was receiving palliative chemotherapy and our team felt she would benefit from short-term inpatient rehabilitation. Within a week of this consult, I saw an 81-year-old woman with an acute myocardial infarction. My team elected to start her on lipid-lowering therapy.
M.D. Minden, M.D., Ph.D., FRCPC
Princess Margaret Hospital
University Health Network
Toronto, ON
Introduction
Leukemias are malignancies of the blood and bone marrow and are classified as either acute or chronic malignancies of the myeloid--red blood cell, granulocyte, platelet lineage--or lymphoid--T or B lymphocyte. In this article we will focus on acute myeloblastic leukemias (AML) and recent advances in their classification and therapy.
Marilyn Schneider, Ph.D.
Executive Director,
Canadian Breast Cancer Research Initiative
Jolie Ringash, MD, MSc
Department of Radiation Oncology,
Princess Margaret Hospital
University Health Network,
Toronto, ON
Haim Cohen, Ph.D
Department of Pathology,
Harvard Medical School,
Boston, MA
Dr. Christine I. Chen, MD, FRCPC
Princess Margaret Hospital,
University Health Network,
Toronto, ON
Anna Liachenko, BSc, MSc
Managing Editor,
Geriatrics & Aging
The relationship between aging and cancer has its basis in cell cycle alterations. While multiple factors affect cell cycle progression, recent research has directed a great deal of attention to telomere length as a key factor affecting mammalian cell proliferation. This article discusses recent findings with respect to the role of telomeres and telomerase in cancer, cellular aging, and longevity.
A group of researchers from Harvard have found evidence that telomere attrition in aging telomerase-deficient mice, heterozygous for the p53 tumour suppressor gene, promotes the development of epithelial cancers.
Jocalyn P. Clark, BSc, MSc