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Serendipity and the Origin of the Lens Implant in Cataract Treatment

Serendipity and the Origin of the Lens Implant in Cataract Treatment

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In 1942, a young British flight surgeon, Ridley, made an outstanding discovery that was to shape the future of cataract treatment. Cataracts result from the clouding of the lens of the eye, which leads to blurred vision. As with the lens of a camera, the lens of the eye functions by focussing light rays onto the retina at the back of the eye, which then transmits this visual information to the brain. For the light to pass through and reach the retina, the lens must remain clear. Cataracts result when the natural lens of the eye becomes cloudy; they are not the product of a growth or the accumulation of film over the eye.

While examining injured fighter pilots, Ridley noted that when plastic slivers from the shattered windshield of an airplane cockpit entered the eye, some pilots had a severe reaction, whereas other pilots had no reaction at all. At the time, the accepted belief was that any foreign material entering the eye would cause a severe reaction until it was removed. Ridley wanted to understand why some pilots showed no reaction to the presence of a piece of plastic in their eye. Further investigation led him to realize that it was only the pilots of Spitfires who did not suffer any complications, whereas pilots flying all other British fighter planes--including captured German pilots flying Messerschmitts--were all severely affected. The young surgeon then discovered that Spitfire plastic came from a different company, ICI, that produced a type of plastic material, polymethyl methacrylate, which could be tolerated by the human eye.

When the war ended in 1945, Ridley turned his attention to cataract surgery. Treatment at the time involved removing the diseased cataract lens and giving the patient thick, heavy glasses that limited their peripheral vision and magnified objects by 30 %. Ridley decided that a better technique for cataract treatment would be to replace the human lens with a lens made of the plastic that he had discovered during the war. On 19 November 1949, at St. Thomas's Hospital in London, he performed the first lens implant on a cataract patient.

Today the treatment of cataracts still relies solely on surgical techniques; there is no medication or diet that can stop a cataract once it has begun to form. A cataract may develop rapidly over a period of a few months or it may grow very slowly over several years. Typically, this process only occurs in a single eye, although eventually, often after months or years, a cataract may develop in the second eye. Most cataracts are related to aging, although they may also be congenital, the result of a medical problem such as diabetes or of a trauma to the eye.

A cataract rarely causes damage if it is left in the eye, except in cases in which there is blurred vision. There are very rare cases, however, of cataracts, when left in the eye long past the stage of blindness, causing inflammation and glaucoma. With the current methods of removal, surgery can be performed successfully at any stage of cataract development.

The only treatment for a cataract is the removal of the cloudy lens. There are various methods of surgically removing a cataract, and the specialist must decide which method is most suitable for each individual patient. For a description of the three main surgical procedures that are available for cataract extraction, and a list of the advantages and disadvantages of these techniques, please see the full article by Dr. Marvin Kwitko on our web site at www.geriatricsandaging.ca.

Dr. Marvin Kwitko performed his first lens implant operation at Bellechasse Hospital in Montreal in 1967. In 1968 he joined St. Mary's Hospital, and under the former chief, Dr. Gaston Duclos, continued this work there. Dr. Kwitko has trained more than 350 surgeons from Canada, the U.S. and abroad. He is currently the Chief of Opthalmology at St. Mary's Hospital in Montreal and an Associate Professor of Ophthalmology at McGill University.

Intramuscular Form of Atypical Antipsychotic Announced

Intramuscular Form of Atypical Antipsychotic Announced

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Anna Liachenko, BSc, MSc
Managing Editor,
Geriatrics & Aging

Due to a favourable side effect profile and high efficacy when compared with typical antipsychotics, atypical drugs are becoming increasingly recommended as first-line treatments for agitation and psychosis related to schizophrenia, manic depression, and behavioural disturbances associated with dementia. At the recent XXII International Congress of Neuro- psychopharmacology (CINP) in Brussels, a new study evaluating an intramuscular (IM) form of Olanzapine (Zyprexa) was presented. An IM form of antipsychotics can be crucial for the rapid control of a patient's psychotic symptoms in an emergency setting. This is the first time that an atypical antipsychotic is available in IM form. The study has just been completed and will be published shortly. Dr. Karena Meehan, M.D., clinical research physician for Eli Lilly and Company and the lead physician for the IM project with responsibility for the Canadian and American groups, agreed to answer a few questions about recent studies on Olanzapine and the use of this drug in the elderly.

Q: Your group has recently presented data comparing the effect of a new IM-formulation of the antipsychotic olanzapine with IM-haloperidol. What were the objectives and the results of your study?

A: The study was designed to compare olanzapine with an older typical antipsychotic.

Cancer, Cellular Senescence and Longevity--The Telomere Connection

Cancer, Cellular Senescence and Longevity--The Telomere Connection

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Anna Liachenko, BSc, MSc
Managing Editor,
Geriatrics & Aging

The relationship between aging and cancer has its basis in cell cycle alterations. While multiple factors affect cell cycle progression, recent research has directed a great deal of attention to telomere length as a key factor affecting mammalian cell proliferation. This article discusses recent findings with respect to the role of telomeres and telomerase in cancer, cellular aging, and longevity.

Telomeres are short DNA repeats located at the ends of eukaryotic chromosomes. Telomeres cap chromosomal ends preventing the loss of important genes during cell division. With every cell division, the length of telomeres decreases unless it is corrected by telomerase, a ribonucleoprotein enzyme that extends the telomeres by adding hexameric nucleotide repeats to the ends of chromosomes. In humans, telomeres are short, and telomerase activity is low in many somatic tissues but is present in germ cells, activated leukocytes, and stem cells from a variety of organs. The study of telomeres has been hampered by the fact that classical animal models, such as mice, have highly active telomerase. This results in long telomeres that do not shorten enough during the animal lifespan to play a significant role in cellular aging. Recently, a genetically altered telomerase-deficient mouse model has been created by a group of researchers at Harvard.

Overcoming Glaucoma: Laser versus Incisional Surgical Approaches

Overcoming Glaucoma: Laser versus Incisional Surgical Approaches

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Choice of Treatment is not Limited by Age but is Case-Specific

Robert M Schertzer, MD, FRCSC
Glaucoma & Anterior Segment Surgery
Multimedia Technology
Medical Director Visual Field and Optic Nerve Head Imaging Units
VHHSC/UBC Eye Care Centre

When pharmaceutical treatment of glaucoma proves ineffective, several surgical options remain available. In fact, some types of glaucoma may be best handled with immediate surgical intervention, even without prior medical management. Ocular surgery is any procedure that causes an alteration in the structure of the eye and can be laser (using a light) or incisional (using microsurgical blades). The type of surgical intervention indicated will depend on the mechanism of the glaucoma.

Laser surgery
There are three types of laser surgery used in treating glaucoma: trabeculoplasty, iridotomy, and cycloablation.

Trabeculoplasty, usually performed with an Argon green laser, is the application of laser energy next to the drainage channels (trabecular meshwork) around the circumference of the iris inside the eye (the coloured part of the eye.) This is used only for open-angle types of glaucoma, especially chronic ("primary") open angle glaucoma, pseudoexfoliation glaucoma, or pigmentary glaucoma.

Pharmaceutical Management of Glaucoma

Pharmaceutical Management of Glaucoma

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Reviewing the Major Classes of Antiglaucoma Medication

Catherine M. Birt, MA, MD, FRCSC
Sunnybrook & Women's College
Health Science Centre,
Assistant Professor,
University of Toronto

Medical management of glaucoma is a field that has expanded dramatically over the past five or six years. Since aging is one of the major risk factors for the development of glaucoma, it is an area that is of great relevance to anyone managing geriatric patients. The purpose of this article is to review the five major classes of antiglaucoma medications, the drugs that are currently available in each class, their indications and their side effects.

Glaucoma is considered to be an optic neuropathy with characteristic optic nerve damage (with loss of the neuroretinal rim and an increased cup-to-disc ratio) and visual field changes (with arcuate field defects progressing to complete loss of peripheral vision). Intraocular pressure (IOP) is not part of the definition of the disease, as many people with statistically elevated IOP do not develop the neuropathy, and many patients with statistically normal IOP do. Intraocular pressure is considered a major risk factor for the development of glaucoma. Other risk factors include advanced age, race, positive family history, myopia, and systemic factors such as diabetes and hypertension. Glaucoma is generally divided into open versus closed angle, and each of these can be subdivided into primary and secondary subtypes.

The Psychosocial Cost of Sensory Deprivation

The Psychosocial Cost of Sensory Deprivation

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Kathleen Jaques Bennett, BSc, BSc, MSc

In Ontario, 71% of the individuals with poor vision are over 65 years of age. To make matters worse, these seniors often suffer from additional sensory deprivation in the form of hearing loss.1 Sensory deprivation can be defined as the partial or complete loss of any of the five senses. It can lead to embarrassment, social isolation, depression, or the labelling of the patient as demented or infantile by family and caregivers. Vision and hearing loss are strongly correlated to an increased risk of mortality over a five-year period,2 probably because the psychosocial effects take an enormous toll on the afflicted individual. The partial or complete loss of the senses can lead to diminished quality of life, and may predispose an elderly person toward other conditions.

Types of Sensory Deprivation
Sensory deprivation can involve the loss of only one sense, or the combined loss of several senses. The loss of visual acuity associated with age often begins with the development of presbyopia. Presbycusis, the loss of hearing, is more prevalent among men than women.7 As well, touch, taste and smell become less acute with time. All of these forms of sensory deprivation undermine an elderly person's ability to live independently, increasing dependence on caregivers, and can result in the infantilization of the elderly individual. When sensory loss is coupled with another condition such as diabetes, the handicap becomes even more severe.

Committing Patients Who are a Danger to Themselves or Others

Committing Patients Who are a Danger to Themselves or Others

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Tracey Tremayne-Lloyd and Lonny J. Rosen
Tremayne-Lloyd Partners,
Toronto, Ontario

Introduction
Of all the symptoms associated with illnesses that commonly affect geriatric patients, the most difficult to manage--for the patient and his or her physician--are those that affect the patient's mental faculties. Physicians attempting to treat geriatric patients who suffer the onset of mental illness, must deal with such issues as the patients' capacity to consent to treatment and their ability to participate in the management of their symptoms, including the regular taking of prescribed medication. While physicians always had tools embedded in provincial mental health legislation to assist them in the care of their mentally ill patients, these tools offered practically no alternative to committing patients to a psychiatric facility, something physicians have been loath to do.

After years of confusion within the mental health system, provincial governments in Mani-toba, Saskatchewan, British Columbia and now Ontario, have passed amendments to their mental health legislation which could lead to better care for people with serious mental disorders, including the elderly.

One of the main purposes of mental health legislation is to allow a medical practitioner to admit, or recommend for admission, to a psychiatric hospital for the purpose of an assessment, persons viewed by the practitioner as constituting a danger to themselves or others.

Recognizing Central Auditory Processing Disorder

Recognizing Central Auditory Processing Disorder

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Hearing Loss in the Elderly Often Coincides with CAPD, Making Diagnosis More of a Challenge

Shechar Dworski, MSc

Hearing is an important part of our sensory system; it enables us to interact with our environment and to communicate verbally with others. Twenty percent of those over the age of 65, and 40% of those over the age of 75, have significant hearing loss, and at least 80% of nursing home residents have some degree of hearing loss.1 There are two types of hearing impairment: peripheral and central. Peripheral damage to the ears can be caused by anything from the build up of cerumen to a perforated eardrum (for a description of peripheral hearing loss, see the articles on Hearing Loss and on Biology of the Aging Ear). Central processing impairment involves the dysfunction of certain areas of the brain's higher auditory centres that are responsible for hearing, language and comprehension. Causes of hearing loss include tumours, ototoxi-city from certain drugs, noise exposure and injury to the cochlear nerve and brain, as well as age-related degeneration of the ear and the associated neural pathways.

Impairments to the hearing process which occur in the brain are called central auditory processing disorders (CAPDs). With CAPDs, hearing impairment seems apparent even in the absence of any peripheral causes of hearing loss. CAPD can be defined as an impaired ability to recognize, discriminate, and/or comprehend auditory information.

New Hearing Aids are Out of Sight

New Hearing Aids are Out of Sight

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Hearing Aid Devices are Tiny Yet Offer Greater Sound Amplification & Less Distortion

Cory Soal, RHAD
Registered Hearing Aid Dispenser

Hearing loss is as individual as a fingerprint. Generally, its progression is so slow that it remains undetected until it has become a real concern. Like any other medical problem, early detection of hearing impairment is important. A proper and thorough hearing test is crucial not only for purposes of diagnosis--it is key to determining what type of hearing aid technology will be the most suitable for a patient.

With the advent of micro-technology, hearing aids have become greatly improved. It is now possible to place more circuitry in a smaller package. Hearing aids can be fitted far into the ear canal and have internal controls that automatically adjust in extreme noise conditions.

First and foremost, a successful fitting of a hearing aid is dependent upon a complete hearing evaluation. A proper hearing test consists of the following components: Pure Tone Air and Bone Conduction tests, Speech Reception Threshold tests, and Speech Discrimination testing. The more accurately hearing is evaluated, the more suitable is the prescription for a hearing aid. There are two important concerns when selecting a hearing instrument. Firstly, the patient must be comfortable with the size of the hearing aid chosen: a patient can be fitted with a Behind-The-Ear (BTE), In-The-Ear (ITE), or the smallest hearing aid that fits Completely-In-The-Canal (CIC).

What is Better for my Elderly Cardiovascular Patient, Surgery or Pharmaceutical Intervention

What is Better for my Elderly Cardiovascular Patient, Surgery or Pharmaceutical Intervention

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Kimby N. Barton, MSc
Assistant Editor,
Geriatrics & Aging

With recent advances in medical interventions for the treatment of cardiovascular diseases, including the introduction of ACE inhibitors and the use of b-blockers for left ventricular dysfunction, the role of coronary revascularization in managing elderly cardiovascular patients has become more difficult to define. Unfortunately, the bulk of research in this area has either failed to compare treatments directly, or has excluded patients who are 65 years or older. Research in this field has also focussed on long-term benefits of surgery over medical treatment, which may not be as germane to an elderly patient as symptomatic improvements, given that this patient's life expectancy may be considerably shorter than that of someone younger. In addition, with the increased frailty that accompanies old age, perioperative mortality and postoperative complications are a much greater concern for elderly patients. They are at an increased risk for stroke, acute renal failure, and other major complications. All of these factors suggest that caution should be exercised when extrapolating data from younger patients and applying it to older ones.