Richard Long, MD, Professor, Department of Medicine, University of Alberta, Edmonton, AB; Chairman, Tuberculosis Committee, Canadian Thoracic Society.

The incidence of tuberculosis increases with age in Canadians. The prevalence of latent tuberculosis infection (LTBI) may also increase with age in Canadians, though information on the age distribution of LTBI is less precise. Chronic inflammatory conditions that currently constitute the major indications for new biologic therapies (tumour necrosis factor inhibitors), such as Crohn's disease and rheumatoid arthritis, often have an older age onset. Biologic therapies have the potential to cause LTBI to progress to active tuberculosis disease. Their use in older Canadians or other populations that may have a higher than average prevalence of LTBI poses a challenge to tuberculosis control.
Key words: tuberculosis, tumour necrosis factor inhibitors, age, rheumatoid arthritis, Crohn's disease.

Results from the Multicentre Randomized Arterial Revascularization Therapy Study

V. Legrand¹ MD, PhD, FESC,
P. Serruys² MD, PhD, FACC, FESC,
WK Lindeboom³ PhD,
M. Vrolix⁴ MD,
G. Fransen⁴ MD,
P. Materne⁵ MD,
G. Dekoster⁵ MD,
R. Seabra-Gomes⁶ MD,FESC,
J. Queiroz E Melo⁶ MD

¹CHU Liege Belgium.
²Thoraxcenter, Rotterdam, The Netherlands.
³Cardialysis, Rotterdam, The Netherlands.
⁴St Jansziekenhuis, Genk, Belgium.
⁵CHR Citadelle, Liege, Belgium.
⁶Hosp Santa Cruz, Carnaxide, Portugal.

Key words : coronary angioplasty, stent, coronary bypass surgery, elderly.

Introduction
As the population ages, an increasing number of elderly patients are presenting with symptomatic multivessel coronary artery disease requiring revascularization. However, the most appropriate myocardial revascularization procedure for older patients with multivessel disease is still controversial. Indeed, it is well recognized that the procedure-related morbidity associated with either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) increases dramatically with age.

Dr. Clarfield is the Chief of Geriatrics, Soroka Hospital Centre, Professor, Faculty of Medicine, Ben Gurion University of the Negev, Beersheva, Israel. Professor (Adjunct), Division of Geriatric Medicine, McGill University and Jewish General Hospital, Montreal, QC, Canada.

Have you ever heard of the wonderful one-hoss shay.
That was built in such a logical way.
It ran a hundred years to a day.
And then, of a sudden, it-ah, but stay.
I'll tell you what happened without delay.
Scaring the parson into fits.
Frightening people out of their wits,
Have you ever heard of that, I say?
Oliver Wendell Holmes

My own grandfather died when he was over 100 years old. Why? We don't know because, for religious reasons, no autopsy was performed. Even if it had been, what might it have shown? Possibly a Whitmore stage A or B carcinoma of the prostate, maybe a tumour in the cecum, perhaps the scars of previous myocardial infarcts, but very likely nothing that a pathologist could confidently have labeled as the cause of death.

So why do old people die? Is aging a disease or is it simply a normal life stage? Or, as Crapo and Fries have so elegantly described in their book "Vitality and Aging" (from which the above quote was lifted), is it simply the final disintegration of the old buggy?

In order to come to some understanding as to what aging actually comprises, it might be helpful to examine what pertains in other mammalian species.

Shabbir M.H. Alibhai, MD, MSc, FRCP(C)
Staff Physician, University Health Network,
Instructor, University of Toronto,
Toronto, ON.

The last few decades have seen major advances in the surgical management of numerous illnesses. As the proportion of the elderly in the general population continues to increase, the prevalence of many chronic conditions also increases. Given the number of available surgical therapeutic options to cure or palliate these chronic conditions, more and more elderly patients are undergoing surgery. Conventional wisdom suggests that, compared to younger or middle-aged patients, older individuals have a higher risk of perioperative and postoperative complications, including death. This increased risk has been attributed to aging itself. This article will examine this relationship in greater detail.

Dozens of studies have suggested that advanced age leads to an increased risk of experiencing surgical complications. This includes an increased risk of postoperative complications such as deep venous thrombosis, infections (including wound, urinary tract, and lung), delirium and mortality.¹ In preoperative assessment clinics, internists and anesthetists utilize risk indices or algorithms to determine an individual patient's surgical risk and potentially modifiable risk factors.