Advertisement

Advertisement

Lecanemab (Leqembi®) in Early Alzheimer’s Disease: A Clinical Guide for Family Physicians in Canada

Teaser: 

D'Arcy Little MD CCFP FCFP FRCPC,

D’Arcy Little, MD, CCFP, FCFP, FRCPC, Medical Director, Journal of Current Clinical Care and www.healthplexus.net Radiologist, Orillia Soldiers’ Memorial Hospital, Assistant Professor, Department of Medical Imaging cross-appointed to Department of Family and Community Medicine, University of Toronto, University of Toronto, Toronto, ON.

CLINICAL TOOLS

Abstract:
Lecanemab (Leqembi®), approved by Health Canada in October 2025, represents Canada’s first disease-modifying therapy for Alzheimer’s disease. This guide reviews patient selection criteria, including mandatory APOE genotyping and amyloid biomarker confirmation, for adults with mild cognitive impairment or mild dementia due to Alzheimer’s disease. Key safety considerations include amyloid-related imaging abnormalities (ARIA), requiring rigorous MRI surveillance protocols. Family physicians play essential roles in early identification, coordinating pre-treatment workups, monitoring for adverse events, and providing collaborative care throughout treatment.

Key Words: Lecanemab, Alzheimer’s disease, amyloid-related imaging abnormalities (ARIA), APOE genotyping, disease-modifying therapy.
Patient Selection: Indicated for adults aged 50-90 with MCI or mild dementia due to Alzheimer’s disease, confirmed amyloid pathology (PET or CSF), and MMSE 22-30. APOE ε4 homozygotes excluded due to elevated ARIA risk.
Pre-Treatment Requirements: Mandatory APOE genotyping, amyloid confirmation, and baseline MRI. Patients with ≥5 microbleeds, macrohemorrhage, superficial siderosis, or anticoagulant use are excluded.
ARIA Monitoring: Imaging abnormalities occur in 13% (edema) and 17% (hemorrhage) of patients, mostly asymptomatic. MRI surveillance required at weeks 4, 8, 12, 26, and 52.
Clinical Efficacy: 27% relative reduction in cognitive decline at 18 months, representing approximately 4-5 months of delayed progression compared to placebo.
NO tPA with ARIA: Patients presenting with stroke-like symptoms should NOT receive thrombolytics until ARIA excluded by MRI. Always alert emergency personnel to lecanemab treatment status.
Anticoagulation Excludes Treatment: All anticoagulant therapy is contraindicated. Review antiplatelet medications during pre-treatment assessment.
ARIA is Usually Silent: 75-80% of cases are asymptomatic. Maintain high suspicion for headache, confusion, or visual changes in first 3 months when risk peaks.
To have access to full article that these tools were developed for, please subscribe. The cost to subscribe is $80 USD per year and you will gain full access to all the premium content on www.healthplexus.net, an educational portal, that hosts 1000s of clinical reviews, case studies, educational visual aids and more as well as within the mobile app.
Related Terms: Radiology, Lecanemab, Alzheimer, amyloid-related imaging abnormalities (ARIA), APOE genotyping, disease-modifying therapy
Disclaimer: 
Disclaimer at the end of each page

Forensic Radiology: A Comprehensive Review for Non-Radiologist Physicians and Medical Students

Teaser: 

D'Arcy Little MD CCFP FCFP FRCPC,

D’Arcy Little, MD, CCFP, FCFP, FRCPC, Medical Director, Journal of Current Clinical Care and www.healthplexus.net Radiologist, Orillia Soldiers’ Memorial Hospital, Assistant Professor, Department of Medical Imaging cross-appointed to Department of Family and Community Medicine, University of Toronto, University of Toronto, Toronto, ON.

CLINICAL TOOLS

Abstract:
Forensic radiology represents the intersection of diagnostic imaging and legal medicine, playing an increasingly vital role in modern medicolegal investigations. This review article provides an overview of forensic radiology for non-radiologist physicians and medical students, covering its historical development, clinical applications, imaging modalities, and medicolegal significance. Key applications include postmortem imaging (virtopsy), identification of deceased individuals, documentation of trauma patterns, detection of non-accidental injury in children, and evaluation of criminal evidence. As imaging technology advances and its integration into forensic pathology increases, understanding the capabilities and limitations of forensic radiology becomes essential for all physicians involved in medicolegal cases. This article aims to provide a foundational knowledge of forensic radiology principles and practices relevant to clinical medicine and legal proceedings.

Key Words: Forensic radiology, postmortem imaging, virtopsy, forensic pathology, medicolegal investigation.
Postmortem CT is the cornerstone of modern forensic radiology, offering rapid whole-body acquisition (5-15 minutes) with excellent skeletal and gas visualization, but the absence of circulation significantly limits soft tissue characterization compared to clinical imaging.
Imaging complements but cannot replace traditional autopsy because it cannot substitute for microscopic tissue examination, toxicology sampling, microbiological cultures, or detection of many disease processes like acute myocardial infarction.
Standardized skeletal surveys are critical for detecting non-accidental injury in children, with classic metaphyseal lesions and posterior rib fractures being highly specific for abuse, and follow-up surveys at 2 weeks increasing diagnostic sensitivity by 27%.
Interpreting postmortem imaging requires specialized expertise to distinguish pathological findings from normal postmortem changes like livor mortis, decomposition gas, and temperature-related density alterations that differ fundamentally from clinical imaging.
PMCT detects more rib fractures than traditional autopsy, particularly posterior and healing fractures obscured by soft tissue, making it superior for documenting thoracic trauma in child abuse cases.
Bilateral skull fractures, fractures crossing suture lines, or complex/depressed fractures in infants suggest inflicted trauma requiring greater force than typical household falls, though absence of skull fracture does not exclude severe head injury.
Three-dimensional CT reconstructions are invaluable for courtroom presentation, allowing judges and juries to understand complex injury patterns, projectile trajectories, and spatial relationships better than 2D images alone.
To have access to full article that these tools were developed for, please subscribe. The cost to subscribe is $80 USD per year and you will gain full access to all the premium content on www.healthplexus.net, an educational portal, that hosts 1000s of clinical reviews, case studies, educational visual aids and more as well as within the mobile app.
Related Terms: Radiology, Forensic radiology, postmortem imaging, virtopsy, forensic pathology, medicolegal investigation
Disclaimer: 
Disclaimer at the end of each page