Darcy Russell, Medical Undergraduate Program, University of British Columbia, Vancouver, BC.
Joseph M. Lam, MD, FRCPC, Clinical Assistant Professor, Department of Pediatrics and Dermatology, University of British Columbia, BC.

Abstract
Acne vulgaris is a common skin condition encountered in family practice and can cause significant distress during adolescence. Treatment options discussed include topical benzyl peroxide, topical retinoids, oral and topical antibiotics, hormonal therapy, and isotretinoin. The following review article provides up-to-date recommendations for treating mild to severe pediatric acne.
Key Words: acne vulgaris, adolescence, treatment, pathogenesis.

Pathogenesis
The pathogenesis of acne involves four steps: (1) sebaceous hyperplasia and increased sebum production, caused by androgens. (2) alterations in follicular growth and differentiation leading to comedone formation. (3) colonization by Propionibacterium acnes (P acnes), which releases inflammatory mediators. (4) the immune response is mounted and inflammation occurs, which when severe can lead to scarring.¹

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